Yes! Molekule is designed to constantly clean your indoor air. It is okay to switch to silent mode regularly as in that mode Molekule is still effective at maintaining clean air, by managing the re-contamination of your room. We recommend that you do not turn Molekule off in order to always keep your air fresh and healthy. If turned off or unplugged, Molekule runs an initial cleaning cycle to catch up with the quality level of the air in the room.